Oxidative and Nitrosative Stress Mediated Renal Cellular Damage Induced by Cyclosporine A: Role of Sulphated Polysaccharides

Role of sulphated polysaccharides from Sargassum Wightii in Cyclosporine A-induced oxidative liver injury in rats

BACKGROUND Seaweeds or marine algae have long been made up a key part of the Asian diet, and as an antioxidant, sulphated polysaccharides have piqued the interest of many researchers as one of the ocean's greatest treasures. The present investigation suggests the therapeutic potential of sulphated polysaccharides from marine brown algae "Sargassum wightii" in Cyclosporine A (CsA)- induced liver...

Replication stress-induced endogenous DNA damage drives cellular senescence induced by a sub-lethal oxidative stress

Although oxidative stress has been shown to induce senescence and replication stress independently, no study has implicated unresolved replication stress as the driver for cellular senescence in response to oxidative stress. Using cells exposed to increasing concentrations of hydrogen peroxide, we show that sub-lethal amount of exogenous hydrogen peroxide induces two waves of DNA damage. The fi...

Metal-Induced Oxidative Stress and Cellular Signaling Alteration in Animals

Contamination by heavy metals has attracted increasing attention considering the ability of these elements in producing serious consequence to ecosystem, and especially on animals health. Due to their widespread use in human activities such as industry, agriculture and even as medicine (e.g. arsenic, selenium and platinum), numerous health risks may be associated with exposure to these substanc...

Oxidative and nitrosative stress in acute renal ischemia.

Generation of reactive oxygen species and nitric oxide in hypoxia-reperfusion injury may form a cytotoxic metabolite, peroxynitrite, which is capable of causing lipid peroxidation and DNA damage. This study was designed to examine the contribution of oxidative and nitrosative stress to the renal damage in ischemic acute renal failure (iARF). iARF was initiated in rats by 45-min renal artery cla...

Oxidative and Nitrosative Stress in the Ischemic Acute Renal Failure